[Mechanism of the effect of diazepam on acetylcholine concentration in mouse brain].
作者信息
Tonkopiĭ V D, Sofronov G A, Aleksandriĭskaia I E, Brestkina L M
出版信息
Biull Eksp Biol Med. 1978;86(7):38-40.
PMID:678649
Abstract
Intraperitoneal injection of diazepam (20 mg/kg) caused an increase of free and bound acetylcholine in the mouse brain. Diazepam pretreatment (20 mg/kg) increased galanthamine anticholinesterase activity and its toxicity; as to physostigmine, armine, and paraoxon toxicity--it remained unchanged. It is supposed that diazepam blocks the release of aetylcholine from the cholinergic nerve terminals which should result in a decrease of functional acetylcholine concentrations in the synapse.
摘要
相似文献
1
[Mechanism of the effect of diazepam on acetylcholine concentration in mouse brain].
Biull Eksp Biol Med. 1978;86(7):38-40.
2
[Galanthamine interaction with mouse brain acetylcholinesterase in in vivo experiments].[加兰他敏在体内实验中与小鼠脑乙酰胆碱酯酶的相互作用]
Biull Eksp Biol Med. 1976 Jul;82(7):823-5.
3
[Effect of phenelzine on the toxicity of cholinergic drugs modified by reserpine].[苯乙肼对利血平修饰的胆碱能药物毒性的影响]
Acta Biol Med Ger. 1971;26(3):551-8.
4
Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat.大鼠在适应慢性、亚急性对氧磷应用过程中乙酰胆碱酯酶的修饰。
Toxicol Appl Pharmacol. 1996 Jan;136(1):20-8. doi: 10.1006/taap.1996.0003.
5
Antagonism of acute physostigmine and neostigmine toxicity in mice by hemicholinium-3.3-半胱氨酸对小鼠急性毒扁豆碱和新斯的明毒性的拮抗作用。
Res Commun Chem Pathol Pharmacol. 1987 Apr;56(1):137-40.
6
In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum.有机磷抗胆碱酯酶对大鼠纹状体中毒蕈碱受体介导的乙酰胆碱释放抑制作用的体外效应
Toxicol Appl Pharmacol. 2002 Jan 15;178(2):102-8. doi: 10.1006/taap.2001.9326.
7
Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.各种胆碱酯酶抑制剂的致癫痫特性比较：地西泮和咪达唑仑的拮抗作用。
Neurotoxicology. 1987 Spring;8(1):113-22.
8
Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors.接触途径对胆碱酯酶抑制剂急性毒性的影响。
Eur J Toxicol. 1970 Nov-Dec;3(6):363-7.
9
Organophosphate-induced convulsions and prevention of neuropathological damages.有机磷酸酯诱导的惊厥及神经病理损伤的预防
Toxicology. 2004 Mar 1;196(1-2):31-9. doi: 10.1016/j.tox.2003.10.013.
10
Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors.用羧酸酯酶抑制剂预防对有机磷抗胆碱酯酶对氧磷的耐受性。
Biochem Pharmacol. 1998 May 1;55(9):1419-26. doi: 10.1016/s0006-2952(97)00650-3.
Zotero 插件