[Galanthamine interaction with mouse brain acetylcholinesterase in in vivo experiments].

Armine treatment of mice against the background of preliminary galanthamine injection diminished the inhibition of the acetylcholinesterase of the brain caused by a reversible inhibitor. This effect was connected with the acetylcholine accumulation and the displacement by it of galanthamine from the active centres of the enzyme. Thus, a competitive character of galanthamine-acetylcholinesterase interaction was shown in vivo.