Iozzo R V, Goldes J A, Chen W J, Wight T N
Cancer. 1981 Jul 1;48(1):89-97. doi: 10.1002/1097-0142(19810701)48:1<89::aid-cncr2820480118>3.0.co;2-b.
Glycosaminoglycans of a malignant pleural mesothelioma have been characterized histochemically and biochemically and compared with those of normal lung, pleural plaque, lung carcinoma, and other connective tissue neoplasms. Chondroitin sulfate constituted the major glycosaminoglycan (approximately 80% of total) present in the pleural mesothelioma while hyaluronic acid was present in only trace amounts (approximately 3% of total). In particular chondroitin 6-sulfate was the predominant isomer, constituting 80% of the total chondroitin sulfate. Control tissue exhibited different proportions of glycosaminoglycans and none of them contained as high an absolute concentration of chondroitin sulfate as the mesothelioma. These findings differ from previous reports demonstrating increased concentration of hyaluronic acid in mesothelioma and suggest the possible existence of a biochemically different form of this neoplasm.
恶性胸膜间皮瘤的糖胺聚糖已通过组织化学和生物化学方法进行了表征，并与正常肺组织、胸膜斑、肺癌及其他结缔组织肿瘤的糖胺聚糖进行了比较。硫酸软骨素是胸膜间皮瘤中主要的糖胺聚糖（约占总量的80%），而透明质酸仅以痕量存在（约占总量的3%）。特别是6-硫酸软骨素是主要的异构体，占硫酸软骨素总量的80%。对照组织中糖胺聚糖的比例不同，且它们中没有一个含有与间皮瘤一样高的硫酸软骨素绝对浓度。这些发现与之前显示间皮瘤中透明质酸浓度增加的报道不同，并提示这种肿瘤可能存在生化形式不同的情况。
