[Combination chemotherapy including anablastine in disseminated breast cancer].

A course of combined therapy (adriablastin, cyclophosphan, vincristine and, in some cases, 5-fluorouracil) was given to 50 breast cancer patients with metastases of different localization. Therapy was conducted in 8 day series spaced by 3--4 week intervals; a total of 135 series were administered. Responses of varying degree was registered in 62% of cases. The said combined chemotherapy is highly effective in treatment of metastatic lesions of bones Out of 19 patients, bone reparation was observed in 8 cases (42.1%) and pronounced symptomatic and subjective improvement -- in 13 cases (68.4%). The suggested schedule of therapy has a low toxic effect and may be recommended for integration with medical practice.