Healy J F, Marshall W H, Brahme F J, White F
AJNR Am J Neuroradiol. 1981 Jul-Aug;2(4):335-8.
Twenty-eight persons with contiguous intracranial skull, and often extracranial metastatic disease are reported. These lesions comprised 7.6% of a series of 250 consecutive patients with intracranial metastatic disease. Only three of 28 patients had other intracranial lesions and only seven of 28 patients has other skull lesions demonstrable on computed tomography (CT). Carcinoma of the prostate and breast, multiple myeloma, and neuroblastoma are especially likely to appear in this manner. All metastases enhanced. The bone destruction was so pervasive that in 19 of the patients it was obvious at routine CT settings. In the nine other patients, it could be clearly seen only at bone settings (high window and level). The CT demonstration of an enhancing intracranial mass involving the skull and often the scalp is highly suggestive but not diagnostic of a metastatic lesion.
报告了28例伴有颅内颅骨连续性病变且常伴有颅外转移疾病的患者。这些病变占连续250例颅内转移疾病患者系列的7.6%。28例患者中只有3例有其他颅内病变，28例患者中只有7例在计算机断层扫描（CT）上显示有其他颅骨病变。前列腺癌、乳腺癌、多发性骨髓瘤和神经母细胞瘤尤其可能以这种方式出现。所有转移灶均有强化。骨质破坏非常广泛，19例患者在常规CT扫描时即可明显显示。另外9例患者只有在骨窗设置（高窗宽和窗位）时才能清楚看到。CT显示颅内肿块强化并累及颅骨及常累及头皮，高度提示但不能确诊为转移瘤。
