Rudowski W J
Ann R Coll Surg Engl. 1981 Mar;63(2):111-7.
The experience of the Department of Surgery of the Institute of Haematology, Warsaw, in surgery in haemophilic patients is discussed. From 1961 to 1980 131 surgical procedures were carried out on 110 patients with a mortality of 4.5%. The principles of replacement therapy, advantages of factor VIII concentrates, and factors influencing the haemorrhagic complications are described. The management of patients with inhibitors of factor VIII and the effect of the 'Feiba' preparation is discussed. Finally the importance of new work on an antihaemophilic globulin-liposome compound for oral administration to haemophilic patients is emphasised.
本文讨论了华沙血液学研究所外科在血友病患者手术方面的经验。1961年至1980年间,对110名患者进行了131例外科手术,死亡率为4.5%。文中描述了替代疗法的原则、凝血因子VIII浓缩物的优点以及影响出血并发症的因素。讨论了凝血因子VIII抑制剂患者的管理以及“菲巴”制剂的效果。最后强调了新型抗血友病球蛋白-脂质体复合物口服给药治疗血友病患者新研究的重要性。