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1980年莫伊尼汉讲座。血友病的大手术

Moynihan Lecture, 1980. Major surgery in haemophilia.

作者信息

Rudowski W J

出版信息

Ann R Coll Surg Engl. 1981 Mar;63(2):111-7.

Abstract

The experience of the Department of Surgery of the Institute of Haematology, Warsaw, in surgery in haemophilic patients is discussed. From 1961 to 1980 131 surgical procedures were carried out on 110 patients with a mortality of 4.5%. The principles of replacement therapy, advantages of factor VIII concentrates, and factors influencing the haemorrhagic complications are described. The management of patients with inhibitors of factor VIII and the effect of the 'Feiba' preparation is discussed. Finally the importance of new work on an antihaemophilic globulin-liposome compound for oral administration to haemophilic patients is emphasised.

摘要

本文讨论了华沙血液学研究所外科在血友病患者手术方面的经验。1961年至1980年间,对110名患者进行了131例外科手术,死亡率为4.5%。文中描述了替代疗法的原则、凝血因子VIII浓缩物的优点以及影响出血并发症的因素。讨论了凝血因子VIII抑制剂患者的管理以及“菲巴”制剂的效果。最后强调了新型抗血友病球蛋白-脂质体复合物口服给药治疗血友病患者新研究的重要性。

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本文引用的文献

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[RESECTION OF THE KNEE JOINT IN A HEMOPHILIAC].
Chir Narzadow Ruchu Ortop Pol. 1963;28:533-7.
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Moynihan of Leeds.利兹的莫伊尼汉。
Ann R Coll Surg Engl. 1966 Jan;38(1):1-21.
7
Clinical investigation of intermediate- and high-purity antihaemophilic factor (factor VIII) concentrates.
Br J Haematol. 1971 Jul;21(1):21-41. doi: 10.1111/j.1365-2141.1971.tb03414.x.
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Extensive surgical procedures in patients with hemophilia A.
Surg Gynecol Obstet. 1972 Oct;135(4):571-6.

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