Benedict W F, Banerjee A, Gardner A, Jones P A
Cancer Res. 1977 Jul;37(7 Pt 1):2202-8.
Various cancer chemotherapeutic agents including alkylating agents, antimetabolites, and antibiotics or natural products were studied for their ability to produce morphological transformation in the C3H/10T1/2 clone 8 mouse cell line and chromosomal damage in the A(T1)C1-3 hamster cell line following a 24-hr exposure of each agent at different concentrations. Those drugs that were known to be carcinogenic in vivo also produced morphological transformation and chromosomal damage, whereas those agents that have not been shown to be carcinogenic in vivo produced neither transformation nor chromosomal lesions. The concentrations used for these studies were in general similar to those actually reached in the plasma of patients treated with these same drugs for malignant, as well as certain nonmalignant, conditions.
研究了多种癌症化疗药物，包括烷化剂、抗代谢物、抗生素或天然产物，观察它们在不同浓度下对C3H/10T1/2克隆8小鼠细胞系产生形态转化以及对A(T1)C1-3仓鼠细胞系造成染色体损伤的能力。每种药物在不同浓度下暴露24小时后进行上述观察。已知在体内具有致癌性的药物也会产生形态转化和染色体损伤，而那些在体内未显示出致癌性的药物既不会产生转化也不会造成染色体损伤。这些研究中使用的浓度通常与使用相同药物治疗恶性以及某些非恶性疾病的患者血浆中实际达到的浓度相似。
