孕妇体内药物与血清蛋白结合的改变：治疗意义。
Altered drug binding to serum proteins in pregnant women: therapeutic relevance.
作者信息
Perucca E, Ruprah M, Richens A
出版信息
J R Soc Med. 1981 Jun;74(6):422-6. doi: 10.1177/014107688107400606.
Abstract
The binding of diazepam, phenytoin and valproic acid to serum proteins in vitro has been compared in pregnant women of different gestational ages and in controls. The unbound fraction of each of three drugs was elevated during pregnancy (particularly during the last 8 weeks) probably due, at least in part, to a fall in serum albumin concentration. These findings may provide a partial explanation for the increase in the clearance of certain drugs during pregnancy and need to be taken into account when interpreting serum drug levels in clinical practice.
摘要
已对不同孕周孕妇及对照组中地西泮、苯妥英和丙戊酸在体外与血清蛋白的结合情况进行了比较。三种药物各自的游离分数在孕期升高（尤其是在孕晚期的最后8周），这可能至少部分归因于血清白蛋白浓度下降。这些发现可能为孕期某些药物清除率增加提供了部分解释，在临床实践中解读血清药物水平时需要考虑到这一点。
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