孕期苯妥英钠和苯巴比妥的血清蛋白结合及游离浓度
Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.
作者信息
Chen S S, Perucca E, Lee J N, Richens A
出版信息
Br J Clin Pharmacol. 1982 Apr;13(4):547-52. doi: 10.1111/j.1365-2125.1982.tb01420.x.
Abstract
1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy.
摘要
1 研究了妊娠对苯妥英钠和苯巴比妥与血清蛋白结合的影响，对象为正常女性和接受药物治疗的癫痫女性。2 两种药物的结合在妊娠期间均降低。这种降低与孕周呈正相关，与血清白蛋白浓度呈负相关。3 尽管游离部分增加，但妊娠晚期苯妥英钠的血清总浓度和游离浓度均降低。
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