Sinclair J C, Torrance G W, Boyle M H, Horwood S P, Saigal S, Sackett D L
N Engl J Med. 1981 Aug 27;305(9):489-94. doi: 10.1056/NEJM198108273050904.
Within the past 15 years, regional neonatal-intensive-care programs have been introduced and have expanded rapidly. The efficacy of some of the individual interventions that constitute neonatal intensive care has been validated in randomized, controlled clinical trials. It is therefore generally assumed that neonatal-intensive-care programs that incorporate these maneuvers are effective in reducing death and disability. However, the overall effectiveness of these programs has not been tested experimentally. Moreover, much of the non-experimental evidence supporting their value is based on the experience of referral units and does not measure the impact on the populations they serve. A definitive economic evaluation of neonatal intensive care has not yet been reported, despite the high cost of such programs. We conclude that neonatal-intensive care programs require further evaluation with rigorous scientific methods.
在过去15年里，区域性新生儿重症监护项目已经被引入并迅速扩展。构成新生儿重症监护的一些单独干预措施的有效性已在随机对照临床试验中得到验证。因此，人们普遍认为，纳入这些操作的新生儿重症监护项目在降低死亡和残疾方面是有效的。然而，这些项目的整体有效性尚未经过实验检验。此外，许多支持其价值的非实验性证据是基于转诊单位的经验，并未衡量对其所服务人群的影响。尽管此类项目成本高昂，但尚未有关于新生儿重症监护的权威性经济评估报告。我们得出结论，新生儿重症监护项目需要用严格的科学方法进行进一步评估。
