Hershey L A, Gift T, Atkins R W, Rivera-Calimlim L
Psychopharmacology (Berl). 1981;73(4):355-8. doi: 10.1007/BF00426465.
Low chloropromazine (CPZ) levels have been measured in chronically treated schizophrenics. We tested six such patients to determine whether a 2-week CPZ-free period (drug holiday) would improve plasma CPZ levels. We also monitored psychiatric symptoms, autonomic function, and extrapyramidal signs. We found these patients to have low predose CPZ levels that did not change appreciably after the drug holiday. Peak levels following the holiday averaged 28 +/- 7 ng/ml higher than those measured prior to the holiday. Drug holidays are safe and should be examined more thoroughly as a means of improving plasma neuroleptic levels in chronically treated schizophrenics.
在长期接受氯丙嗪（CPZ）治疗的精神分裂症患者中检测到其血药浓度较低。我们对6名此类患者进行了测试，以确定停药2周（药物假期）是否会提高血浆CPZ水平。我们还监测了精神症状、自主神经功能和锥体外系体征。我们发现这些患者服药前CPZ水平较低，药物假期后并无明显变化。假期后的峰值水平平均比假期前测得的水平高28±7 ng/ml。药物假期是安全的，作为提高长期接受治疗的精神分裂症患者血浆抗精神病药物水平的一种方法，应进行更全面的研究。
