Ambrosius H
Acta Histochem Suppl. 1980;22:11-8.
A review is given about some biochemical problems in the biosynthesis of immunoglobulins. The following problems are discussed: the specialty of the antibody biosynthesis in comparison to the production of other proteins, antigen binding by lymphocyte receptors, the process of the synthesis of H- and L-chains, the formation of immunoglobulin molecules and their secretion, primary and the secondary immune responses and their regulation, theories of antibodies formation and the problem of the origin of the high number of v genes.
本文综述了免疫球蛋白生物合成中的一些生化问题。讨论了以下问题:与其他蛋白质产生相比,抗体生物合成的特殊性;淋巴细胞受体的抗原结合;重链和轻链的合成过程;免疫球蛋白分子的形成及其分泌;初次和二次免疫应答及其调节;抗体形成理论以及大量可变基因的起源问题。