Biewenga W J, van den Brom W E
Res Vet Sci. 1981 Mar;30(2):158-60.
The glomerular filtration rate (GFR) was determined with the single injection 51Cr-EDTA clearance in 48 dogs with renal disease and the results were compared with the plasma Creatinine (PC) and plasma urea (PU) levels. The superiority of PC values over PU values for the assessment of the GFR is represented by the power functions PC = 78.2 CR(-0.67) mmol per litre and PU = 10.3 Cr(-0.52) mmol per litre, in which Cr is the relative glomerular filtration rate. The higher correlation between PC and Cr (r = 0.834) than between PU and Cr (r = 0.693) also demonstrates this superiority. An extended two compartment analysis of the 51Cr-EDTA plasma disappearance curve is not essential for diagnostic purposes.
采用单次注射51Cr-乙二胺四乙酸清除率法测定了48只患有肾脏疾病犬的肾小球滤过率（GFR），并将结果与血浆肌酐（PC）和血浆尿素（PU）水平进行比较。用于评估GFR时，PC值优于PU值，其幂函数分别为PC = 78.2 CR(-0.67) mmol/升和PU = 10.3 Cr(-0.52) mmol/升，其中Cr为相对肾小球滤过率。PC与Cr之间的相关性（r = 0.834）高于PU与Cr之间的相关性（r = 0.693），这也证明了这种优越性。对于诊断目的而言，对51Cr-乙二胺四乙酸血浆消失曲线进行扩展的二室分析并非必要。
