Draper D L, James J F, Hadley W K, Sweet R L
Sex Transm Dis. 1981 Apr-Jun;8(2):43-50. doi: 10.1097/00007435-198104000-00001.
An investigation of the MICs of various antibiotics and the nutritional requirements (auxotypes) of Neisseria gonorrhoeae recovered from the cervix, fallopian tubes, and peritoneal cavity of women with acute salpingitis was done. These MICs and auxotypes were compared to those of gonococci isolated from the cervix of women with uncomplicated or asymptomatic genital tract gonorrhea. The MICs of minocycline, penicillin G, ampicillin, cefoxitin, and cefaclor for gonococci isolated from women with acute salpingitis were significantly higher. Significant differences in auxotype patterns were identified between isolates from salpingitis cases and uncomplicated cases. The prototrophic form was the most common (75%) among salpingitis strains. No strains requiring arginine, hypoxanthine, and uracil were identified among the salpingitis isolates. In contrast, strains that required these nutrients were the most frequent auxotype among isolated from women with uncomplicated genital tract gonorrhea. Discriminant analysis revealed that the MIC of minocycline and the auxotype were the most powerful discriminators between groups of patients with different manifestations of gonorrhea.
对从患有急性输卵管炎的女性的子宫颈、输卵管和腹腔中分离出的淋病奈瑟菌的各种抗生素的最低抑菌浓度（MIC）及其营养需求（营养缺陷型）进行了调查。将这些MIC和营养缺陷型与从不复杂或无症状生殖道淋病的女性子宫颈中分离出的淋球菌的MIC和营养缺陷型进行了比较。从患有急性输卵管炎的女性中分离出的淋球菌对米诺环素、青霉素G、氨苄西林、头孢西丁和头孢克洛的MIC显著更高。在输卵管炎病例和不复杂病例的分离株之间发现了营养缺陷型模式的显著差异。原养型在输卵管炎菌株中最为常见（75%）。在输卵管炎分离株中未发现需要精氨酸、次黄嘌呤和尿嘧啶的菌株。相比之下，需要这些营养物质的菌株是从不复杂生殖道淋病女性中分离出的最常见的营养缺陷型。判别分析显示，米诺环素的MIC和营养缺陷型是不同表现形式淋病患者组之间最有力的判别因素。
