Meningioangiomatosis in the absence of von Recklinghausen's disease.

Two patients who had been having seizures for 10 years or longer were found to have a peculiar neoplastic alteration in the cerebral cortex. The lesion in both instances consisted of a combined proliferation of meningothelial and endothelial cells; and are best described as meningioangiomatosis. The tissues were surgically excised and the frequency and severity of the patients' seizures decreased. In neither instance were there stigmata of von Recklinghausen's disease. In one example, as long as 8 years after craniotomy, no evidence of any disorder of the peripheral nerve was found. A review showed that such lesions have always been associated with multiple intracranial and spinal neoplasms; therefore, these two patients appear to be unique.