Steffes M W, Nielsen O, Dyrberg T, Baekkeskov S, Scott J, Lernmark A
Transplantation. 1981 Jun;31(6):476-9. doi: 10.1097/00007890-198106000-00017.
Diabetic A.TL and A.TH mice, congenic inbred strains differing only in the I and S (non-K, non-D) regions of the major histocompatibility (H-2) complex, received intrasplenic allogeneic and isogeneic pancreatic islet transplants. The isografts were uniformly accepted, while approximately 60% of the recipients receiving allografts rejected the islets, most within 4 weeks of transplantation. With either strain the animals accepting the allografts had higher blood glucose values than normal mice or isografted recipients. After a minimum of 13 weeks of nearly normal glucose levels, successfully allografted mice received skin grafts and spleen cells. None of the A.TH recipients rejected the A.TL islets, but two of four A.TL recipients of A.TH islets became diabetic after the skin grafts. These observations suggest a variable response to islet transplanted across this isolated difference of the H-2 complex. Furthermore, allografted islets resisting rejection did not provide normal glucose levels in the recipients.
糖尿病A.TL和A.TH小鼠是仅在主要组织相容性（H-2）复合体的I区和S区（非K区、非D区）存在差异的同基因近交系，接受了脾内同种异体和同基因胰岛移植。同基因移植均被接受，而接受同种异体移植的受体中约60%排斥胰岛，大多数在移植后4周内发生排斥。无论哪种品系，接受同种异体移植的动物血糖值均高于正常小鼠或接受同基因移植的受体。在血糖水平接近正常至少13周后，成功接受同种异体移植的小鼠接受了皮肤移植和脾细胞。没有一只A.TH受体排斥A.TL胰岛，但接受A.TH胰岛移植的四只A.TL受体中有两只在皮肤移植后出现糖尿病。这些观察结果表明，对于跨越H-2复合体这一孤立差异进行移植的胰岛，反应存在差异。此外，抵抗排斥的同种异体移植胰岛并未使受体的血糖水平恢复正常。
