Moroni F, Malthe-Sorenssen D, Cheney D L, Costa E
Brain Res. 1978 Jul 14;150(2):333-41. doi: 10.1016/0006-8993(78)90284-6.
The septal-hippocampal cholinergic pathway of the rat was either electrically stimulated or lesioned in order to study whether or not acetylcholine turnover rate (TRACh) changes with the activity of the cholinergic neurons. Appropriate electrical stimulation of the septum selectively increased the TRACh in the hippocampus in nonanesthetized and in barbiturate-treated animals. The ACh content of the hippocampus increased by approximately 30% 1 h after fimbria lesions, but decreased by about 80% 9 days after fimbria lesions. Acute fimbria lesions decreased the TRACh in the lesioned side by approximately 85%, but the TRACh in the intact side and in the cortex was unchanged. The same was true in rats with chronic fimbria lesions. In conclusion, the hippocampal TRACh increases or decreases proportionally to the activity of the cholinergic neurons; therefore the measurement of this parameter is of particular value in understanding how postynaptic cholinergic neurons are modulated by putative neurotransmitter released from afferent nerve terminals.
为了研究乙酰胆碱周转率（TRACh）是否随胆碱能神经元的活动而变化，对大鼠的隔-海马胆碱能通路进行了电刺激或损伤。对隔区进行适当的电刺激可选择性地增加未麻醉动物和巴比妥类药物处理动物海马中的TRACh。海马的乙酰胆碱含量在海马伞损伤后1小时增加约30%，但在海马伞损伤9天后减少约80%。急性海马伞损伤使损伤侧的TRACh降低约85%，但完整侧和皮质中的TRACh未发生变化。慢性海马伞损伤的大鼠也出现同样情况。总之，海马中的TRACh与胆碱能神经元的活动成比例地增加或减少；因此，测量该参数对于理解突触后胆碱能神经元如何被传入神经末梢释放的假定神经递质调节具有特殊价值。
