Mount M E, Oehme F W
Arch Environ Contam Toxicol. 1981 Jul;10(4):483-95. doi: 10.1007/BF01055444.
Sheep were used to study the effect of carbaryl in liver, heart, and brain and on cholinesterase activity. Carbaryl residues greater than or equal to 0.01 ppm in the brain were present in all sheep dying after dosing. Sheep dying acutely had higher levels of carbaryl and greater than or equal to 50% inhibition of brain cholinesterase activity, while sheep with prolonged death had lower carbaryl levels and less cholinesterase inhibition. Prolonged deaths were associated with pulmonary embarrassment, enteritis, hyperthermia, and metabolic acidosis. Carbaryl was rapidly degraded in stored blood samples but was stable in dead brain tissue.
使用绵羊来研究西维因对肝脏、心脏和大脑的影响以及对胆碱酯酶活性的影响。所有给药后死亡的绵羊大脑中均存在大于或等于0.01 ppm的西维因残留。急性死亡的绵羊西维因水平较高，大脑胆碱酯酶活性抑制率大于或等于50%，而死亡时间延长的绵羊西维因水平较低，胆碱酯酶抑制作用较小。死亡时间延长与肺部窘迫、肠炎、体温过高和代谢性酸中毒有关。西维因在储存的血液样本中迅速降解，但在死亡的脑组织中稳定。
