Barbacid M, Stephenson J R, Aaronson S A
Cell. 1977 Apr;10(4):641-8. doi: 10.1016/0092-8674(77)90097-6.
Several low molecular weight proteins of endogenous type C viruses of the RD114/baboon group are compared with the gag gene translational products of endogenous type C viruses of murine origin. The p10 proteins of each virus group are shown to be immunologically and biochemically related, while the p12 proteins of RD114/baboon viruses are demonstrated to share antigenic determinants with murine viral p15. Moreover, highly type-specific phosphoproteins, p15 of RD114/baboon viruses and p12 of murine viruses, are shown to possess very similar biochemical properties. These findings, along with previous studies indicating immunologic cross-reactivity between their major internal antigens, p30, demonstrate that each of the gag gene-coded proteins of murine type C viruses has a analogue in viruses of the RD114/baboon group. The immunologic and biochemical relatedness of their gag gene translational products supports the concept of a common progenitor in the evolution of these endogenous viruses.
将RD114/狒狒组内源性C型病毒的几种低分子量蛋白质与鼠源内源性C型病毒的gag基因翻译产物进行了比较。结果表明，每组病毒的p10蛋白在免疫和生化方面具有相关性，而RD114/狒狒病毒的p12蛋白与鼠病毒的p15具有共同的抗原决定簇。此外，RD114/狒狒病毒的高度型特异性磷蛋白p15和鼠病毒的p12具有非常相似的生化特性。这些发现，连同先前表明其主要内部抗原p30之间存在免疫交叉反应性的研究，证明鼠C型病毒的每个gag基因编码蛋白在RD114/狒狒组病毒中都有类似物。它们gag基因翻译产物的免疫和生化相关性支持了这些内源性病毒在进化过程中有共同祖先的概念。
