Lamberg B A, Tikkanen M J
Br Med J (Clin Res Ed). 1981 Aug 15;283(6289):461-2. doi: 10.1136/bmj.283.6289.461.
Hypercalcaemia is a recognised complication of hypothyroidism. We describe three patients who developed hypercalcaemia after thyroidectomy when thyroid supplements were discontinued. They were treated with thyroxine, dihydrotachysterol, and calcium after operation, and in all three cases serum calcium concentrations remained constant during combined treatment. Thyroxine treatment was discontinued several weeks before a radioiodine scan was performed; dihydrotachysterol and calcium were continued throughout. Serum calcium concentrations rose to hypercalcaemic levels in all cases. Elimination of dihydrotachysterol from plasma may be delayed in hypothyroidism, resulting in hypervitaminosis D. It is advisable to reduce the dose of dihydrotachysterol and to check serum calcium concentrations regularly in patients whose thyroid treatment is interrupted.
高钙血症是甲状腺功能减退症的一种公认并发症。我们描述了3例患者，他们在甲状腺切除术后停用甲状腺补充剂后出现了高钙血症。术后他们接受了甲状腺素、双氢速甾醇和钙剂治疗，在所有3例患者中，联合治疗期间血清钙浓度保持稳定。在进行放射性碘扫描前几周停用了甲状腺素治疗；双氢速甾醇和钙剂则一直持续使用。所有病例中血清钙浓度均升至高钙血症水平。甲状腺功能减退症患者血浆中双氢速甾醇的清除可能会延迟，从而导致维生素D过多症。对于甲状腺治疗中断的患者，建议减少双氢速甾醇的剂量并定期检查血清钙浓度。
