Spitz I M, Halperin Y, Zylber-Haran E, Shilo S, Leroith D, Liel Y, Livshin J, Laufer N, Schenker J
Clin Endocrinol (Oxf). 1981 Apr;14(4):375-80. doi: 10.1111/j.1365-2265.1981.tb00623.x.
The aim of the present study was to measure the PRL response to metoclopramide (MET) and chlorpromazine (CPZ) in seventeen patients with primary testicular failure and eight patients with isolated gonadotrophin deficiency (IGD). The responses were compared with those to TRH. Basal gonadotrophins and peak responses to LHRH were increased in testicular failure and reduced in IGD. Basal PRL levels were normal in both groups of patients. However, when compared with controls, the PRL response to both MET and CPZ as well as to TRH was exaggerated in primary testicular failure, whereas the responses wee decreased in IGD. In both patient groups, as well as in the controls, the PRL response to MET exceeded that to TRH and CPZ. It is suggested that alterations in the steroid milieu are responsible for the exaggerated PRL response to MET, CPZ and TRH in primary testicular failure and the reduced response observed in IGD.
本研究的目的是测定17例原发性睾丸功能衰竭患者和8例孤立性促性腺激素缺乏（IGD）患者对胃复安（MET）和氯丙嗪（CPZ）的催乳素（PRL）反应。将这些反应与对促甲状腺激素释放激素（TRH）的反应进行比较。睾丸功能衰竭患者的基础促性腺激素和对促黄体生成素释放激素（LHRH）的峰值反应增加，而IGD患者则降低。两组患者的基础PRL水平均正常。然而，与对照组相比，原发性睾丸功能衰竭患者对MET、CPZ以及TRH的PRL反应均增强，而IGD患者的反应则降低。在两组患者以及对照组中，对MET的PRL反应均超过对TRH和CPZ的反应。提示类固醇环境的改变是原发性睾丸功能衰竭患者对MET、CPZ和TRH的PRL反应增强以及IGD患者反应降低的原因。
