黄褐黑盘孢（奥特）韦姆的深层培养法生产抗生素

Antibiotic production by submerged culture of Melanconis flavovirens (Otth) Wehm.

作者信息

Sasek V, Gupta A R

出版信息

Folia Microbiol (Praha). 1981;26(2):124-8. doi: 10.1007/BF02927367.

Abstract

The pyrenomycete Melanconis flavovirens under submerged cultivation produced antibiotics active against both bacteria and fungi. Glucose and corn-steep liquor were the best C and N sources for the antibiotic production, respectively. Supplementation with Tween-80 and enthylene glycol stimulated both antifungal and antibacterial antibiotic production, whereas oleic acid only the antifungal one. Addition of K2HPO4 also showed a positive effect. The optimal conditions for fermentation of the antifungal component are given.

摘要

在深层培养条件下，核菌纲真菌黄变黑团壳菌可产生对细菌和真菌均有活性的抗生素。葡萄糖和玉米浆分别是抗生素生产中最佳的碳源和氮源。添加吐温 - 80和乙二醇可刺激抗真菌和抗细菌抗生素的产生，而油酸仅刺激抗真菌抗生素的产生。添加磷酸氢二钾也显示出积极作用。文中给出了抗真菌成分发酵的最佳条件。