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关于支气管哮喘中使用丙种维生素丁油剂的一些临床统计观察

A few clinical statistical observations on the use of Solganal-B-Oleosum n bronchial asthma.

作者信息

Okatani Y

出版信息

J Asthma Res. 1980 Jul;17(4):165-73. doi: 10.3109/02770908009105667.

Abstract

In my clinic, Solganal-B-Oleosum was administered to the patients with bronchial asthma from 1955 up to 1973, covering a period of 19 years, and statistical observation has been done. Several clinical results are presented. 1) In 1,056 cases, markedly improved 40.8%, improved 32.8%; clinically effective ratio: total 73.6%. Others: a few somewhat improved and unimproved cases, then inconsiderable aggravated cases. 2) The longer the period from the age of onset to the beginning of treatment, the lower the efficiency; the shorter the period, the higher the efficiency. 3) The group of light severity revealed high efficiency; and according to the grade of severity the efficiency decreased. 4) Sex, age, age of onset, disposition of asthma, etc., resulted in no clear relation to the effectiveness. 5) Side effect revealed 2.3% skin eruption, and then a few cases of proteinuria, stomatitis, gingivitis, etc. There was no case of severe, critical disorder. 6) In other cases, long-term effectiveness after finishing the Solganal treatment was pursued. A trial of additional injection for several years after finishing the treatment was also studied. Serum gold concentrations in the course and after finishing the main course etc., were measured.

摘要

1955年至1973年期间,我所在的诊所对支气管哮喘患者使用了硫代苹果酸金钠油剂进行治疗,历时19年,并进行了统计观察。现将部分临床结果呈现如下:1)1056例患者中,显著改善者占40.8%,改善者占32.8%;临床有效率总计为73.6%。其他情况:有少数稍有改善和未改善的病例,以及极个别病情加重的病例。2)从发病年龄到开始治疗的时间间隔越长,疗效越低;间隔越短,疗效越高。3)轻度严重程度组显示出高疗效;且根据严重程度等级,疗效逐渐降低。4)性别、年龄、发病年龄、哮喘倾向等与疗效无明显关联。5)副作用方面,有2.3%的患者出现皮疹,还有少数几例蛋白尿、口腔炎、牙龈炎等。未出现严重的、危急的病症。6)在其他病例中,对硫代苹果酸金钠治疗结束后的长期疗效进行了追踪。还研究了治疗结束后数年进行追加注射的试验。测定了治疗期间及主要疗程结束后的血清金浓度等。

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