McMillan E M, Wasik R, Everett M A
J Am Acad Dermatol. 1981 Sep;5(3):274-9. doi: 10.1016/s0190-9622(81)70092-6.
A monoclonal antibody, OKT 6, has been developed against an antigen which is expressed by immature T cells as part of their normal intrathymic differentiation, but not by mature peripheral T cells. It was though that a search for the expression of such an antigen might be worthwhile in prelymphomatous conditions. This communication describes the investigation of lymphocytic infiltrates of atropic parapsoriasis, lymphomatoid papulosis, and a small group of miscellaneous skin conditions with OKT 6 and the immunoperoxidase technic. OKT 6-positive cells were identified in the dermis in varying numbers in four cases of atrophic parapsoriasis and in one case of lymphomatoid papulosis, but not in any of the other disorders. Positive epidermal staining was noted in all tissues examined. The pattern obtained suggested that epidermal dendritic cells may react with OKT 6. The findings indicate that OKT 6-positive cells may be found outside the thymus in certain conditions. The observations in epidermis cast doubt on the exact nature of the positively reacting cells observed in dermis, suggesting that may either be immature thymocytes or possibly Langerhans cells.
一种名为OKT 6的单克隆抗体已被研制出来，它针对的抗原是未成熟T细胞在胸腺内正常分化过程中表达的一部分，但成熟的外周T细胞不表达。人们认为，在淋巴瘤前期病症中寻找这种抗原的表达情况可能是有价值的。本报告描述了用OKT 6和免疫过氧化物酶技术对萎缩性副银屑病、淋巴瘤样丘疹病以及一小群其他皮肤病症的淋巴细胞浸润情况进行的研究。在4例萎缩性副银屑病和1例淋巴瘤样丘疹病的真皮层中发现了数量不等的OKT 6阳性细胞，但在其他任何病症中均未发现。在所检查的所有组织中均观察到表皮呈阳性染色。所获得的模式表明表皮树突状细胞可能与OKT 6发生反应。研究结果表明，在某些情况下，胸腺外可能会发现OKT 6阳性细胞。在表皮的观察结果对在真皮中观察到的阳性反应细胞的确切性质提出了质疑，表明它们可能要么是未成熟胸腺细胞，要么可能是朗格汉斯细胞。
