Westermann U, Merker H J
MMW Munch Med Wochenschr. 1981 Jul 10;123(28):1142-4.
The almost 100% successes with drug prophylaxis of cheilognathopalatoschisis in humans described by some authors are dubious, not only because of the dose level, but particularly because of the fact that the data do not result from controlled studies. In order to clarify the efficacy of cleft prophylaxis, we undertook animal experiments. To produce clefts, NMRI mice were treated with dexamethasone on day 13 of pregnancy. Another group also received a deproteinized hemoderivative in addition from day 11 to day 18 and two other groups were used as controls. It was found on autopsy shortly before birth that the incidence of clefts was significantly lower in the animals treated with additional hemoderivative.
一些作者所描述的在人类中药物预防唇腭裂几乎100%成功的说法值得怀疑，这不仅是因为剂量水平，更特别的是因为这些数据并非来自对照研究。为了阐明预防腭裂的效果，我们进行了动物实验。为了产生腭裂，在怀孕第13天给NMRI小鼠注射地塞米松。另一组从第11天到第18天还额外接受了一种去蛋白血液衍生物，另外两组用作对照。在出生前不久进行尸检时发现，额外接受血液衍生物治疗的动物中腭裂的发生率显著较低。
