Gustafson R O, McDonald T J, O'Duffy J D, Goellner J R
Otolaryngol Head Neck Surg. 1981 May-Jun;89(3 Pt 1):409-13. doi: 10.1177/019459988108900311.
Behçet's disease is a chronic inflammatory disorder of undetermined cause. The most frequent manifestations are aphthous ulceration of the upper aerodigestive tract, genital ulcers, ocular inflammation, and arthritis. Less frequent features include involvement of the CNS, thrombophlebitis, and large-vessel arteritis. Of utmost importance is the fact that aphthous ulceration of the upper aerodigestive tract will develop in all patients who have Behçet's disease; thus, they may come to the otorhinolaryngologist for evaluation. This disease must be distinguished from recurrent aphthous ulceration, herpes simplex infection, Stevens-Johnson syndrome, Reiter's disease, pemphigus, systemic lupus erythematosus, and Crohn's disease. Behçet's disease is diagnosed on the basis of clinical features; no specific laboratory abnormalities have been noted. The histopathologic perivasculitis is non-specific. Corticosteroid administration has been the most efficacious treatment. For serious complications, such as uveitis or meningoencephalitis, immunosuppressive agents can be used.
白塞病是一种病因不明的慢性炎症性疾病。最常见的表现是上消化道和呼吸道的阿弗他溃疡、生殖器溃疡、眼部炎症和关节炎。较少见的特征包括中枢神经系统受累、血栓性静脉炎和大血管动脉炎。至关重要的是，所有白塞病患者都会出现上消化道和呼吸道的阿弗他溃疡；因此，他们可能会去找耳鼻喉科医生进行评估。这种疾病必须与复发性阿弗他溃疡、单纯疱疹感染、史蒂文斯-约翰逊综合征、赖特综合征、天疱疮、系统性红斑狼疮和克罗恩病相鉴别。白塞病是根据临床特征诊断的；尚未发现特异性实验室异常。组织病理学上的血管周围炎是非特异性的。使用皮质类固醇一直是最有效的治疗方法。对于严重并发症，如葡萄膜炎或脑膜脑炎，可使用免疫抑制剂。
