Beitins I Z
Prim Care. 1981 Mar;8(1):3-18.
A thorough understanding of the events and hormonal changes which accompany puberty can be successfully utilized to diagnose adolescent menstrual disorders. Knowledge regarding the maturational events within the hypothalamic-pituitary-ovarian axis and the expected times at which positive feedback leading to ovulation occurs is helpful in the design of optimal therapeutic regimens. It should be emphasized that the immature hypothalamic-pituitary-ovarian axis is extremely sensitive to low doses of estrogen and suppression may hinder maturation to normal cyclic activity. Therefore, forms of therapy other than oral contraceptives should be sought and prescribed for adolescents with menstrual disorders.
对伴随青春期的各种事件和激素变化有透彻的了解，可成功用于诊断青少年月经失调。了解下丘脑 - 垂体 - 卵巢轴内的成熟事件以及导致排卵的正反馈预期发生时间，有助于设计最佳治疗方案。应当强调的是，不成熟的下丘脑 - 垂体 - 卵巢轴对低剂量雌激素极为敏感，抑制可能会阻碍其成熟为正常的周期性活动。因此，对于患有月经失调的青少年，应寻求并开具除口服避孕药以外的其他治疗方式。
