Gundlach A L, Beart P M
Psychopharmacology (Berl). 1981;74(1):71-3. doi: 10.1007/BF00431760.
The effect of IV and IP muscimol on the concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in both the nigrostriatal and mesolimbic dopaminergic pathways has been studied. IV muscimol (2 mg/kg), produced significant decreases in the concentration of DA in both DA systems, while the concentration of DOPAC remained unaltered. However, IP muscimol (5 and 10 mg/kg) caused significant increases in the concentrations of DA or DOPAC in all brain regions examined. Our results suggest differential actions of muscimol on DA metabolism dependent upon the route of administration.
已研究了静脉注射和腹腔注射蝇蕈醇对黑质纹状体和中脑边缘多巴胺能通路中多巴胺（DA）和3,4 - 二羟基苯乙酸（DOPAC）浓度的影响。静脉注射蝇蕈醇（2毫克/千克）使两个多巴胺系统中的DA浓度显著降低，而DOPAC的浓度保持不变。然而，腹腔注射蝇蕈醇（5和10毫克/千克）导致在所检查的所有脑区中DA或DOPAC的浓度显著增加。我们的结果表明，蝇蕈醇对DA代谢的作用因给药途径而异。
