Oscós-Alvarado A, Martínez de Muñoz D
Psychopharmacology (Berl). 1981;74(1):93-6. doi: 10.1007/BF00431764.
Early reports suggest a relationship between pentylenetetrazol-induced convulsions (PTZ) and amnesia. 4,-Hydroxy,4-phenyl caproamide (YPCA) is potently anti-convulsant against PTZ-induced convulsions. The purpose of these experiments is to show the possible role of PTZ in these amnestic effects. Experiment 1 proves YPCA antagonism of PTZ-induced convulsions in mice. Experiment 2 shows how YPCA, injected before PTZ and after animal training, protects against convulsions, leaving memory storage unaffected. However, when YPCA is injected before training (10 and 5 min) and PTZ 15 min afterwards (5 and 10 min after training), a retention impairment was observed. The results are discussed in terms that emphasize the need of convulsions in retrograde amnesia. Experiment 3 shows that foot shock is necessary for passive avoidance acquisition. Experiment 4 shows that subconvulsive doses of PTZ (5,10,20, and 40 mg/kg-1) have no effect on memory.
早期报告表明戊四氮诱发惊厥（PTZ）与失忆之间存在关联。4-羟基-4-苯基己酰胺（YPCA）对PTZ诱发的惊厥具有强大的抗惊厥作用。这些实验的目的是展示PTZ在这些失忆效应中可能发挥的作用。实验1证明了YPCA对小鼠PTZ诱发惊厥的拮抗作用。实验2表明，在PTZ注射前以及动物训练后注射YPCA，可预防惊厥，且不影响记忆存储。然而，当在训练前（10分钟和5分钟）注射YPCA，15分钟后（训练后5分钟和10分钟）注射PTZ时，观察到记忆保持受损。结果的讨论强调了逆行性失忆中惊厥的必要性。实验3表明足部电击对于被动回避学习是必要的。实验4表明亚惊厥剂量的PTZ（5、10、20和40毫克/千克-1）对记忆没有影响。
