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阿糖胞苷对小鼠白血病L1210细胞和被升麻糖苷抑制核苷转运的小鼠骨髓祖细胞的细胞毒性差异。

Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside.

作者信息

Hemmi H

出版信息

Res Commun Chem Pathol Pharmacol. 1981 Jun;32(3):565-8.

PMID:6791252
Abstract

Cytotoxicities of cytosine arabinoside (Ara C) and showdomycin to murine L1210 leukemia cells was prevented by a nucleoside transport inhibitor, cimicifugoside. Ara C toxicity to bone marrow progenitor cells, however, was observed even in the presence of cimicifugoside. The difference of Ara C toxicity toward L1210 cells and bone marrow cells pretreated with cimicifugoside may be originated in the different characteristics of membrane transport site of nucleosides.

摘要

胞嘧啶阿拉伯糖苷（Ara C）和showdomycin对小鼠L1210白血病细胞的细胞毒性可被核苷转运抑制剂升麻糖苷阻止。然而，即使在存在升麻糖苷的情况下，仍观察到Ara C对骨髓祖细胞的毒性。Ara C对用升麻糖苷预处理的L1210细胞和骨髓细胞毒性的差异可能源于核苷膜转运位点的不同特性。

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