生长和青春期延迟男孩对促黄体生成素释放激素（LH-RH）的促性腺激素反应。
Gonadotrophin response to LH-RH in boys with delayed growth and adolescence.
作者信息
Savage M O, Preece M A, Cameron N, Jones J, Theintz G, Penfold J L, Tanner J M
出版信息
Arch Dis Child. 1981 Jul;56(7):552-6. doi: 10.1136/adc.56.7.552.
Abstract
Plasma luteinising hormone (LH) and follicle-stimulating hormone (FSH) concentrations were measured before and after intravenous luteinising hormone-releasing hormone (LH-RH) in 33 boys with growth delay. Eighteen were prepubertal and 15 pubertal. Basal LH and FSH levels were low in both groups with mean increments after LH-RH of 3.2 +/- 0.8 U/l (mean +/- SEM) and 2.6 +/- 0.4 U/l respectively in the prepubertal and 7.4 +/- 0.7 U/l and 2.0 +/- 0.3 U/l in the pubertal boys. The LH increment showed a positive correlation with increasing bone age (r = 0.71, P less than 0.001); FSH did not. The LH-RH response thus appeared normal in relation to the stage of maturity.
摘要
对33名生长发育迟缓的男孩在静脉注射促黄体生成素释放激素（LH-RH）前后测定了血浆促黄体生成素（LH）和促卵泡生成素（FSH）的浓度。其中18名处于青春期前，15名处于青春期。两组的基础LH和FSH水平均较低，青春期前男孩在注射LH-RH后的平均增加值分别为3.2±0.8 U/l（平均值±标准误）和2.6±0.4 U/l，青春期男孩则为7.4±0.7 U/l和2.0±0.3 U/l。LH增加值与骨龄增加呈正相关（r = 0.71，P＜0.001）；FSH则不然。因此，LH-RH反应相对于成熟阶段而言似乎是正常的。
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