Kirschbaum B B, Koontz W W, Olichney M J
Arch Intern Med. 1981 Sep;141(10):1361-3.
A patient with renal failure and light-chain proteinuria showed roentgenographic evidence of retroperitoneal fibrosis on further examination. Diffuse hyperglobulinemia, low levels of C3 and C4, and elevated C1q binding were noted. Biopsy specimens of the kidney and retroperitoneal tissue disclosed a dense pleomorphic cellular infiltrate with a preponderance of plasma cells. Renal function improved slowly after ureterolysis and institution of prednisone therapy. The case emphasizes the immunologic features of the early phase of idiopathic retroperitoneal fibrosis.
一名患有肾衰竭和轻链蛋白尿的患者在进一步检查时显示出腹膜后纤维化的X线证据。发现有弥漫性高球蛋白血症、低水平的C3和C4以及升高的C1q结合。肾脏和腹膜后组织的活检标本显示有密集的多形性细胞浸润，以浆细胞为主。输尿管松解术和泼尼松治疗后肾功能缓慢改善。该病例强调了特发性腹膜后纤维化早期的免疫学特征。
