[锌对血清胸腺因子（胸腺素）抗原性的修饰作用]
[Modification of the antigenicity of the serum thymic factor (thymulin) by zinc].
作者信息
Pleau J M, Dardenne M, Bach J F
出版信息
C R Seances Acad Sci III. 1981 May 11;292(17):991-3.
We have previously reported that the serum thymic factor (FTS) exists under two forms, one deprived of zinc, biologically inactive and another one containing zinc, biologically active for which we have proposed the name of thymulin (FTS-Zn). A new iodinated tracer (125I FTS-Zn) has been prepared by fixing zinc on synthetic FTS. This tracer is recognized by a Rabbit anti-FTS antiserum at a 1/20,000 dilution. Normal Mouse sera displace the binding of FTS-Zn to the antiserum (40-60% inhibition) whereas thymectomized mouse sera have no effect. These results should allow the establishment of a simple radioimmunoassay for thymulin (FTS-Zn) present in biological fluids.
我们之前报道过，血清胸腺因子（FTS）以两种形式存在，一种不含锌，无生物活性，另一种含锌，具有生物活性，我们已将其命名为胸腺素（FTS-Zn）。通过将锌固定在合成FTS上制备了一种新的碘化示踪剂（125I FTS-Zn）。这种示踪剂在1/20,000稀释度下能被兔抗FTS抗血清识别。正常小鼠血清能取代FTS-Zn与抗血清的结合（40-60%抑制），而胸腺切除小鼠血清则无此作用。这些结果应有助于建立一种针对生物体液中胸腺素（FTS-Zn）的简单放射免疫测定法。
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