Savino W, Dardenne M, Bach J F
Clin Exp Immunol. 1983 Apr;52(1):1-6.
The number of thymic epithelial cells containing the serum thymic factor (FTS or thymulin), assessed by indirect immunofluorescence using an anti-FTS monoclonal antibody, was studied in the thymus of normal and autoimmune mice as a function of age. In normal mice the number of FTS+ cells was constant until the age of 6 months and then began to decline. In autoimmune strains, the age linked decline was premature being already significant at 10 weeks of age. These findings were paralleled by the age associated decline of FTS blood levels in all strains studied. Double labelling experiments showed that in both normal and autoimmune mice, FTS+ cells were Ia negative, suggesting that these cells belong to a specific subpopulation of the thymic epithelial reticulum.
采用抗血清胸腺因子（FTS或胸腺素）单克隆抗体通过间接免疫荧光法评估含血清胸腺因子的胸腺上皮细胞数量，研究了正常和自身免疫小鼠胸腺中该细胞数量随年龄的变化。在正常小鼠中，FTS +细胞数量在6个月龄前保持恒定，然后开始下降。在自身免疫品系中，与年龄相关的下降出现过早，在10周龄时就已显著。在所有研究品系中，这些发现与FTS血液水平随年龄的下降情况相似。双重标记实验表明，在正常和自身免疫小鼠中，FTS +细胞均为Ia阴性，这表明这些细胞属于胸腺上皮网状组织的一个特定亚群。
