Taxy J B, Battifora H, Trujillo Y, Dorfman H D
Cancer. 1981 Sep 15;48(6):1381-91. doi: 10.1002/1097-0142(19810915)48:6<1381::aid-cncr2820480621>3.0.co;2-6.
Fifteen malignant schwannomas were examined by light and electron microscopy. Five tumors arose in patients with neurofibromatosis and five were contiguous with a peripheral nerve (Group I). Five tumors met neither of these generally accepted diagnostic criteria but were light microscopically seen as compatible with malignant schwannoma when examined under light microscope (Group II). In the better differentiated areas of Group I lesions, long, overlapping, tightly packed cytoplasmic processes were parallel to homogeneous flocculent material, occasionally assuming a linear appearance suggesting basal lamina. In Group II, similar cytoplasmic processes were present but the extracellular material was less extensive and had a less obvious relationship to the plasma membrane. In neither group were fine intracytoplasmic filaments prominent. Malignant schwann cells are seldom as ultrastructurally differentiated as their benign counterparts. Nevertheless, within the context of well-studied light microscopy and the sampling error inherent in ultrastructural examination, electron microscopy can support the diagnosis of malignant schwannoma.
对15例恶性神经鞘瘤进行了光镜和电镜检查。5例肿瘤发生于神经纤维瘤病患者，5例与周围神经相邻（第一组）。5例肿瘤均不符合这些公认的诊断标准，但在光镜检查时，镜下表现符合恶性神经鞘瘤（第二组）。在第一组病变分化较好的区域，长的、相互重叠且紧密排列的胞质突起与均匀的絮状物质平行，偶尔呈线性外观，提示有基底膜。在第二组中，也存在类似的胞质突起，但细胞外物质较少，与质膜的关系也不那么明显。两组中均未见明显的胞质细丝。恶性神经鞘细胞在超微结构上很少像其良性对应物那样分化良好。然而，在经过充分研究的光镜检查以及超微结构检查固有的抽样误差范围内，电镜检查可支持恶性神经鞘瘤的诊断。
