Ip C, Sinha D
Carcinogenesis. 1981;2(5):435-8. doi: 10.1093/carcin/2.5.435.
The present investigation reports the effect of selenium supplementation on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats fed either a 5% or a 25% corn oil diet. A reduction in tumorigenesis in both groups was observed with 2.5 p.p.m. of dietary selenium. Selenium supplementation also inhibited the development of hyperplastic alveolar nodules in the mammary gland subsequent to DMBA treatment. In addition, the appearance of mammary neoplasia was reduced by selenium in rats fed a high-saturated fat diet (coconut oil), indicating that the type of fat consumed did not influence the antitumorigenic effectiveness of selenium. The lack of a correlation between the anticarciongenic efficacy of selenium and its ability to suppress lipid peroxidation in the mammary tissue of rats fed either a high-saturated fat or a high-unsaturated fat diet suggests that the inhibitory action of selenium is probably not mediated by its antioxidant function in lipid metabolism
本研究报告了在喂食5%或25%玉米油饮食的大鼠中，补充硒对7,12-二甲基苯并[a]蒽（DMBA）诱导的乳腺癌发生的影响。在饮食中添加2.5 ppm的硒后，两组的肿瘤发生均有所减少。补充硒还抑制了DMBA处理后乳腺中增生性肺泡结节的发展。此外，在喂食高饱和脂肪饮食（椰子油）的大鼠中，硒减少了乳腺肿瘤的出现，这表明所摄入脂肪的类型并不影响硒的抗肿瘤效果。在喂食高饱和脂肪或高不饱和脂肪饮食的大鼠乳腺组织中，硒的抗癌功效与其抑制脂质过氧化的能力之间缺乏相关性，这表明硒的抑制作用可能不是通过其在脂质代谢中的抗氧化功能介导的
