Buvat J, Buvat-Herbaut M
J Gynecol Obstet Biol Reprod (Paris). 1981;10(2):99-108.
The authors describe the hormone changes that occur in a normal woman throughout the menstrual cycle. These is no circadian rhythm in the release of gonadotrophins after puberty. LH is liberated in a pulsatile way throughout the day and the periodicity and amplitude of the episodes vary throughout the cycle with a notable peak of this hormone before ovulation. The level of FSH is greater early in the follicular phase and in mid-cycle, where there is also a cycle together with that of the LH. In spite of these variations a single estimation of gonadotrophins does represents their secretion over 24 hours. The changes in total and free oestradiol and in oestrone are parallel. There are two maxima, the one being preovulatory and preceding the gonadotrophin peak and the other throughout the whole luteal phase. Progesterone changes little throughout the day. It is low during the follicular phase and gradually starts to rise before the preovulatory peak of gonadotrophins, and stays raised throughout the whole luteal phase, following during this phase a variable curve. The 17 hydroxyprogesterone is similarly low in the follicular phase. Its cycle peak is stronger and its rise in the luteal phase weaker than that of progesterone. The secretion of androgens is marked by changes throughout the day of a circadian nature (maximal for dehydroepiandrosterone and delta 5 androstenediol) and cyclic (especially for androstenediol which rises in mid-cycle). Prolactin secretion is marked by changes throughout the day, circadian (maximum during the night) and cyclical (minimum follicular, maximum preovulatory, with a luteal level higher than the follicular level). These changes should be considered in order to work out correctly the levels of hormones that should be prescribed on the precise dates and worked out in accordance with the date of menstruation and temperature curve taken throughout the cycle.
作者描述了正常女性在整个月经周期中发生的激素变化。青春期后促性腺激素的释放不存在昼夜节律。促黄体生成素（LH）全天以脉冲方式释放，其发作的周期性和幅度在整个周期中有所变化，在排卵前该激素会出现明显峰值。卵泡期早期和周期中期促卵泡生成素（FSH）水平较高，此时FSH水平也与LH水平一起呈周期性变化。尽管存在这些变化，但单次测定促性腺激素确实能反映其24小时的分泌情况。总雌二醇和游离雌二醇以及雌酮的变化是平行的。有两个最大值，一个在排卵前，先于促性腺激素峰值出现，另一个在整个黄体期。孕酮在一天中变化不大。在卵泡期较低，在促性腺激素排卵前峰值出现之前逐渐开始升高，并在整个黄体期保持升高，在此阶段遵循一条可变曲线。17-羟孕酮在卵泡期同样较低。其周期峰值比孕酮更强，在黄体期的升高比孕酮更弱。雄激素的分泌具有昼夜性质的全天变化（脱氢表雄酮和δ5雄烯二醇最高）和周期性变化（尤其是雄烯二醇在周期中期升高）。催乳素的分泌具有昼夜变化（夜间最高）和周期性变化（卵泡期最低，排卵前最高，黄体期水平高于卵泡期水平）。为了正确计算在精确日期应开具的激素水平，并根据整个周期的月经日期和体温曲线来确定，应考虑这些变化。
