Caldwell J H, Kirschner S D, Spagna V A, Inloes R L
J Clin Gastroenterol. 1981 Mar;3(1):43-6. doi: 10.1097/00004836-198103000-00010.
We studied a young man with persistent elevation of transaminases and indirect bilirubin following acute viral hepatitis. Liver biopsy showed chronic persistent hepatitis, and clinical evaluation was otherwise negative for significant liver disease. The indirect-reacting serum bilirubin rose after both caloric restriction and intravenous nicotinic acid, responses believed by some to be characteristic of Gilbert's syndrome. Fasting and postprandial serum bile acid conjugates were not elevated. These results suggest that "Gilbert's-like" aberrations in bilirubin metabolism may be part of the spectrum of chronic persistent hepatitis.
我们研究了一名急性病毒性肝炎后转氨酶和间接胆红素持续升高的年轻男性。肝活检显示为慢性持续性肝炎，而临床评估在其他方面未发现明显肝脏疾病。热量限制和静脉注射烟酸后，间接反应性血清胆红素均升高，一些人认为这些反应是吉尔伯特综合征的特征。空腹和餐后血清胆汁酸结合物未升高。这些结果表明，胆红素代谢中的“类吉尔伯特”异常可能是慢性持续性肝炎谱系的一部分。
