牛奶中的离子钙与山羊乳腺上皮的完整性。
Ionized calcium in milk and the integrity of the mammary epithelium in the goat.
作者信息
Neville M C, Peaker M
出版信息
J Physiol. 1981;313:561-70. doi: 10.1113/jphysiol.1981.sp013682.
Abstract
- Injection of citrate or EGTA solutions into the lumen of the mammary gland of goats in quantities sufficient to reduce ionized calcium to less than one-tenth of normal, led to increases in milk concentrations of Na and Cl and decreases in K and lactose. 2. Subsequent milk yields were decreased in glands treated with citrate but not in those treated with EGTA. 3. Blood-milk potential difference decreased (i.e. towards zero) in glands in which citrate was present. 4. In goats milked hourly with the aid of oxytocin, milk Na and Cl concentrations increased while K and lactose decreased; there was no apparent decrease in Ca2+ concentration. 5. It is suggested that ionized calcium in milk is essential to preserve the integrity of the mammary epithelium during lactation.
摘要
- 向山羊乳腺管腔内注射足以将游离钙降低至正常水平十分之一以下的柠檬酸盐或乙二醇双四乙酸（EGTA）溶液，会导致牛奶中钠和氯的浓度升高，钾和乳糖的浓度降低。2. 用柠檬酸盐处理的腺体随后的产奶量下降，但用EGTA处理的腺体则没有。3. 存在柠檬酸盐的腺体中血乳电位差降低（即趋向于零）。4. 在借助催产素每小时挤奶一次的山羊中，牛奶中钠和氯的浓度升高，而钾和乳糖的浓度降低；钙离子浓度没有明显下降。5. 有人提出，牛奶中的游离钙对于维持泌乳期间乳腺上皮的完整性至关重要。
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