Bischoff K
MMW Munch Med Wochenschr. 1981 Sep 4;123(36):1337-40.
In an acute trial on the bicycle ergometer, the beta-receptor blocker atenolol in single morning doses of 50 mg produced a significant reduction in blood pressure, heart rate and ischaemic changes in the ECG. Parallel to this there was an increase in the load resistance of the patients. The majority of the parameters show no further changes at double the dosage. In the chronic trial with treatment periods of four weeks each, the substance is distinctly superior to placebo with regard to the frequency of angina.
在一项自行车测力计的急性试验中，单次晨起服用50毫克的β受体阻滞剂阿替洛尔可使血压、心率和心电图缺血性改变显著降低。与此同时，患者的负荷阻力增加。大多数参数在剂量加倍时未显示进一步变化。在每个治疗期为四周的慢性试验中，就心绞痛发作频率而言，该药物明显优于安慰剂。
