Pushkarev I A, Bruveris U A, Guseva L N, Lazovskiĭ I P
Vopr Med Khim. 1981 May-Jun;27(3):417-23.
Using polyacrylamide gel disc electrophoresis in presence of sodium dodecylsulfate (SDS) urinary proteins were studied in apparently healthy persons, in patients with chronic glomerulonephritis, chronic interstitial nephritis as well as in patients with myeloma, urine of which contained monoclonic light chains of immunoglobulins. SDS polyacrylamide gel disc electrophoresis is a suitable procedure for differential diagnosis of glomerular and tubulo-interstitial impairments of kidney. In some cases the procedure enables to ascertain not only the type but also severity of the kidney impairment as well as to study dynamics of the disease without a recourse to such invasive methods as kidney biopsy.
采用十二烷基硫酸钠（SDS）存在下的聚丙烯酰胺凝胶圆盘电泳法，对健康人、慢性肾小球肾炎患者、慢性间质性肾炎患者以及骨髓瘤患者（其尿液中含有免疫球蛋白单克隆轻链）的尿蛋白进行了研究。SDS聚丙烯酰胺凝胶圆盘电泳是一种适用于鉴别诊断肾脏肾小球和肾小管间质损伤的方法。在某些情况下，该方法不仅能够确定肾脏损伤的类型，还能确定其严重程度，并且无需借助肾活检等侵入性方法就能研究疾病的动态变化。
