Formation of 8,11,12-trihydroxyeicosatrienoic acid by a rat lung high-speed supernatant fraction.
作者信息
Pace-Asciak C R, Mizuno K, Yamamoto S
出版信息
Biochim Biophys Acta. 1981 Aug 24;665(2):352-4. doi: 10.1016/0005-2760(81)90021-7.
PMID:6793080
Abstract
An enzyme was found in the high-speed (100 000 x g) supernatant fraction of a rat lung homogenate which catalysed the conversion of arachidonic acid into 8,11,12-trihydroxyeicosatrienoic acid. The isomeric 8,9,12-triol was not detected. The structure of the isolated product was confirmed by mass spectrometric analysis of the methyl ester t-butyldimethylsilyl ether derivative. These results indicate that formation of both positional isomers is carried out by separate enzymes, the distributions of which are not restricted to platelets.
摘要
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