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大鼠胎儿肝脏糖原的周转

Turnover of liver glycogen in the rat foetus.

作者信息

Gilbert M, Bourbon J

出版信息

Biochem J. 1978 Dec 15;176(3):785-9. doi: 10.1042/bj1760785.

DOI:10.1042/bj1760785
PMID:106841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186301/
Abstract

Incorporation and release of the radioactivity in the liver glycogen of 18.5- and 19.5-day-old rat foetuses were studied after intravenous injection of E11-14C]glycerol. Incorporation occurred during 1 h after injection of the radioactive tracer to the foetus; then, the incorporated radioactivity decreased. Glycogen content in the liver, and glycogen phosphorylase and glycogen synthase were not modified during the experiment. It is therefore postulated that a physiological turnover of glycogen exists in the liver of the rat foetus.

摘要

在静脉注射[E11-14C]甘油后,研究了18.5日龄和19.5日龄大鼠胎儿肝脏糖原中放射性的掺入和释放情况。放射性示踪剂注射到胎儿体内后1小时内发生了掺入;然后,掺入的放射性降低。实验过程中肝脏中的糖原含量、糖原磷酸化酶和糖原合酶均未发生改变。因此推测大鼠胎儿肝脏中存在糖原的生理性周转。

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本文引用的文献

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A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose.一种用于UDP葡萄糖-糖原葡萄糖基转移酶的快速滤纸测定法,包括改进的UDP-14C-葡萄糖生物合成。
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Effect of insulin on glycogen synthesis in fetal rat liver in organ culture.胰岛素对器官培养的胎鼠肝脏糖原合成的影响。
Endocrinology. 1973 Feb;92(2):584-8. doi: 10.1210/endo-92-2-584.
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Glycogen metabolism in the liver of the foetal rat.胎鼠肝脏中的糖原代谢
Biochem J. 1974 May;140(2):331-40. doi: 10.1042/bj1400331.
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Hormonal regulation of glycogen metabolism in neonatal rat liver.新生大鼠肝脏中糖原代谢的激素调节
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The role of glucose, glucagon and glucocorticoids in the regulation of liver glycogen synthesis.
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[Variations of the fetal adnexa liquid volume of the rat and the level of blood hematocrit of the vitelline vessels under the influence of maternal dehydration and adrenaline].
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A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes.一种测定少量组织或分离的肝细胞中糖原含量和放射性的快速方法。
Anal Biochem. 1976 Mar;71(1):96-105. doi: 10.1016/0003-2697(76)90014-2.
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Origin and metabolic fate of plasma glycerol in the rat and rabbit fetus.
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