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多巴胺和章鱼胺在海兔中诱发的电压依赖性电流。

Voltage-dependent current evoked by dopamine and octopamine in Aplysia.

作者信息

Pellmar T C

出版信息

Brain Res. 1981 Nov 2;223(2):448-54. doi: 10.1016/0006-8993(81)91163-x.

DOI:10.1016/0006-8993(81)91163-x
PMID:6793213
Abstract

Octopamine and dopamine evoke a slow voltage-dependent inward current in neurons of Aplysia. The responses are present only at depolarized potentials (greater than -40 mV). They are insensitive to changes in potassium, persist after removal of sodium, are not reduced by low chloride solution, and are blocked by cadmium. Because of the similarities in voltage-dependence, time course and ionic sensitivities, the ionic mechanism of the voltage-dependent responses to octopamine and dopamine are concluded to be the same as that of the voltage-dependent response to serotonin reported previously.

摘要

章鱼胺和多巴胺可在海兔神经元中诱发一种缓慢的电压依赖性内向电流。这些反应仅出现在去极化电位(大于 -40 mV)时。它们对钾离子变化不敏感,在去除钠离子后仍持续存在,不受低氯溶液影响,并被镉阻断。由于在电压依赖性、时间进程和离子敏感性方面存在相似性,因此得出结论,对章鱼胺和多巴胺的电压依赖性反应的离子机制与先前报道的对5-羟色胺的电压依赖性反应相同。

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