环磷酸腺苷引发的电压依赖性电流的离子机制
Ionic mechanism of a voltage-dependent current elicited by cyclic AMP.
作者信息
Pellmar T C
出版信息
Cell Mol Neurobiol. 1981 Mar;1(1):87-97. doi: 10.1007/BF00736041.
Abstract
Intracellular pressure injection of cyclic AMP induces a slow voltage-dependent inward current in some neurons of Aplysia californica. The time course, voltage dependence, and ionic sensitivities of this response are nearly identical to those of the voltage-dependent calcium current induced by serotonin in the same preparation. The response to cyclic AMP is unaffected by changes in the extracellular concentration of chloride or potassium. The current is slowly but minimally reduced by a sodium-free solution. The calcium channel blocker, cadmium, blocks the current elicited by injection of cyclic AMP. The data presented here suggest that cyclic AMP can induce a voltage-dependent calcium current.
摘要
向加州海兔的某些神经元内注射环磷酸腺苷（cAMP）会诱发一种缓慢的电压依赖性内向电流。该反应的时间进程、电压依赖性和离子敏感性与同一标本中5-羟色胺诱发的电压依赖性钙电流几乎相同。对环磷酸腺苷的反应不受细胞外氯化物或钾浓度变化的影响。无钠溶液会使该电流缓慢但轻微降低。钙通道阻滞剂镉可阻断注射环磷酸腺苷所诱发的电流。本文给出的数据表明，环磷酸腺苷可诱发电压依赖性钙电流。
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