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由第七条免疫球蛋白重链同种异型位点控制的小鼠IgE等位基因多态性。

Allelic polymorphism of murine IgE controlled by the seventh immunoglobulin heavy chain allotype locus.

作者信息

Borges M S, Kumagai Y, Okumura K, Hirayama N, Ovary Z, Tada T

出版信息

Immunogenetics. 1981;13(6):499-507. doi: 10.1007/BF00343718.

DOI:10.1007/BF00343718
PMID:6793508
Abstract

Two alloantisera against hybridoma-derived IgE detected allotypic determinants expressed on the murine epsilon chain. An antiserum raised in BALB/c mice against monoclonal IgE of C57BL/6 origin reacted exclusively with IgE of strains having Igh-1b (IgG2 a) allotype. The second antiserum, C57BL/6 anti-BALB/c monoclonal IgE, reacted with IgE of strains having Igh-1a, Igh-1d, Igh-1e and Igh-1j allotypes. The genetic studies of (BALB/c x C57BL/6)F1 and backcross F2 animals indicated that the locus controlling the IgE allotype is linked to the Igh-1 locus. This was further confirmed by the possession of respective IgE allotypes by Igh-C congenic mice, BALB/c and BAB-14, C3H.SW/Hz and CWB/Hz. Thus, the allotype detected on the epsilon chain is controlled by the seventh murine immunoglobulin allotype locus, and should be designated as the Igh-7 allotype.

摘要

两种针对杂交瘤来源的IgE的同种异体抗血清检测到了在鼠ε链上表达的同种异型决定簇。在BALB/c小鼠中产生的针对C57BL/6来源的单克隆IgE的抗血清仅与具有Igh-1b（IgG2 a）同种异型的品系的IgE发生反应。第二种抗血清，C57BL/6抗BALB/c单克隆IgE，与具有Igh-1a、Igh-1d、Igh-1e和Igh-1j同种异型的品系的IgE发生反应。对（BALB/c×C57BL/6）F1和回交F2动物的遗传学研究表明，控制IgE同种异型的基因座与Igh-1基因座连锁。Igh-C同源小鼠BALB/c和BAB-14、C3H.SW/Hz和CWB/Hz各自具有相应的IgE同种异型，进一步证实了这一点。因此，在ε链上检测到的同种异型由第七个鼠免疫球蛋白同种异型基因座控制，应指定为Igh-7同种异型。

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引用本文的文献

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Construction of a monoclonal antibody against Igh-7b.
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3
Studies on IgE production in mice. I. Spontaneous suppression of IgE production in SJA/9 mice.
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Polymorphism of heavy chain immunoglobulin isotypes in the Mus subgenus. I. Limited gamma 3 polymorphism revealed by antibodies raised in SPE wild-derived inbred strain.小家鼠亚属重链免疫球蛋白同种型的多态性。I. 由SPE野生来源近交系产生的抗体揭示的有限γ3多态性。

本文引用的文献

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B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA/9 mice do not provide evidence for isotype switching without gene deletion.在感染巴西日圆线虫的SJA/9小鼠中，同时表达表面IgM和IgE的B细胞并未提供无基因缺失情况下的同种型转换证据。
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Immunology. 1967 Feb;12(2):113-31.
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Identification of gamma-E-antibodies as a carrier of reaginic activity.鉴定γ-E抗体作为反应素活性的载体。
J Immunol. 1967 Dec;99(6):1187-98.
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Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy.近交系、抗原及抗原剂量组合对小鼠免疫反应性和反应素产生的影响。一种人类特应性过敏免疫方面的潜在小鼠模型。
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