同种异型近交系小鼠中杂交瘤细胞IgE分泌的抑制：同种异型b小鼠中T细胞对同种异型7a的抑制
Suppression of IgE secretion from hybridoma cells in allotype congenic mice: suppression of allotype 7a by T cells in allotype b mice.
作者信息
Maekawa S, de Szalay C, Ovary Z
出版信息
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8134-8. doi: 10.1073/pnas.82.23.8134.
Abstract
Anti-2,4-dinitrophenyl (DNP) IgE producing hybridoma B 53 when injected subcutaneously is established equally well in syngeneic BALB/c (heavy-chain allotype a) and congenic CB20 (heavy-chain allotype b) mice. However, secretion of anti-DNP IgE monoclonal antibody is greatly suppressed in CB20 mice. B 53 cells taken from the subcutaneous tumors of CB20 mice produce anti-DNP IgE in vivo in BALB/c mice and in vitro. No difference was observed in IgE production between these cells and the controls taken from BALB/c mice. The suppression of IgE production was due to T cells and/or their product(s) of CB20 mice.
摘要
产生抗2,4 - 二硝基苯基（DNP）IgE的杂交瘤B 53皮下注射时，在同基因的BALB/c（重链同种异型a）和同类系CB20（重链同种异型b）小鼠中生长情况相同。然而，CB20小鼠中抗DNP IgE单克隆抗体的分泌受到极大抑制。取自CB20小鼠皮下肿瘤的B 53细胞在BALB/c小鼠体内及体外均能产生抗DNP IgE。这些细胞与取自BALB/c小鼠的对照细胞在IgE产生方面未观察到差异。IgE产生的抑制是由于CB20小鼠的T细胞和/或其产物。
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