一种巯基蛋白酶抑制剂E-64-c对钙诱导的Z线去除的抑制作用。
Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.
作者信息
Ishiura S, Nonaka I, Sugita H
出版信息
J Biochem. 1981 Jul;90(1):283-5.
PMID:6793567
Abstract
A new thiol-protease inhibitor, E-64-c (N-[N-(L-3-carboxyoxirane-2-carbonyl)-L-leucyl]-isoamylamine), specifically suppressed the disappearance of the Z-line terminal by calcium in rat soleus muscle. This results suggests that calcium-activated neutral protease (CANP) may be involved in such calcium-mediated degeneration of myofilaments.
摘要
一种新的巯基蛋白酶抑制剂E-64-c（N-[N-(L-3-羧基环氧乙烷-2-羰基)-L-亮氨酰]-异戊胺）特异性地抑制了大鼠比目鱼肌中钙引起的Z线末端消失。这一结果表明，钙激活中性蛋白酶（CANP）可能参与了这种钙介导的肌丝退化。
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