日粮中抗坏血酸水平对喂食多氯联苯的豚鼠生长、肝脏脂质过氧化及血脂的影响。

Effect of dietary level of ascorbic acid on the growth, hepatic lipid peroxidation, and serum lipids in guinea pigs fed polychlorinated biphenyls.

作者信息

Kato N, Kawai K, Yoshida A

出版信息

J Nutr. 1981 Oct;111(10):1727-33. doi: 10.1093/jn/111.10.1727.

DOI:10.1093/jn/111.10.1727

Abstract

Rats exposed to polychlorinated biphenyls (PCB) or other xenobiotics exhibit an increase in tissue and urinary ascorbic acid, serum cholesterol and hepatic lipid peroxidation. To clarify the physiological role of ascorbic acid in exposure to PCB, we studied the influence of dietary levels of ascorbic acid (30-2,000 ppm) on the growth, serum lipids and hepatic lipid peroxidation in guinea pigs fed 50 ppm PCB-containing diets. The results showed that the growth depression due to PCB was ameliorated by increasing dietary ascorbic acid. The increases in serum cholesterol and phospholipid and in hepatic lipid peroxidation due to PCB were suppressed by larger amounts of ascorbic acid, which inversely correlated with the changes in growth. PCB intake also increased serum levels of cortisol and triglyceride, but these effects were not influenced by dietary level of ascorbic acid. The optimum requirement of ascorbic acid in the guinea pigs fed PCB was 800-2,000 ppm in the diet for the changes in the growth, serum cholesterol and hepatic lipid peroxidation.

摘要

接触多氯联苯（PCB）或其他外源性物质的大鼠，其组织和尿液中的抗坏血酸、血清胆固醇及肝脏脂质过氧化水平会升高。为阐明抗坏血酸在接触PCB过程中的生理作用，我们研究了饮食中不同水平的抗坏血酸（30 - 2000 ppm）对喂食含50 ppm PCB饮食的豚鼠生长、血脂及肝脏脂质过氧化的影响。结果表明，增加饮食中的抗坏血酸可改善因PCB导致的生长抑制。大量抗坏血酸可抑制因PCB引起的血清胆固醇、磷脂及肝脏脂质过氧化的增加，且这种抑制与生长变化呈负相关。摄入PCB还会使血清皮质醇和甘油三酯水平升高，但这些影响不受饮食中抗坏血酸水平的影响。对于喂食PCB的豚鼠，在生长、血清胆固醇及肝脏脂质过氧化方面发生变化时，饮食中抗坏血酸的最佳需求量为800 - 2000 ppm。