Kato N, Tani T, Yoshida A
J Nutr. 1980 Aug;110(8):1686-94. doi: 10.1093/jn/110.8.1686.
Effects of dietary level of protein on liver microsomal drug-metabolizing enzyme system, lipids and urinary ascorbic acid metabolism were studied in the rats fed 0.1% polychlorinated biphenyl (PCB) containing diets. In the rats not receiving PCB, the activity of the enzyme system increased as the protein level was increased up to around 35%. In a short-term experiment (8-9 days), dietary PCB caused an increase in the activity of the enzyme system regardless of dietary level of protein. In a semi-long term experiment (29-30 days), however, 35-55% protein diets did not allow for induction to the same extent. As a result the highest activity was observed with 10-20% protein diets in this period. The increments in urinary ascorbic acid and in serum cholesterol were generally potentiated with high-protein diets. Maximum increments in urinary ascorbic acid and serum cholesterol were obtained with 20% protein and 35% protein, respectively, in the semi-long term experiment. In contrast to serum cholesterol, the accumulation of liver cholesterol and triglyceride due to PCB was markedly potentiated with low-protein diets.
在喂食含0.1%多氯联苯（PCB）日粮的大鼠中，研究了日粮蛋白质水平对肝脏微粒体药物代谢酶系统、脂质和尿抗坏血酸代谢的影响。在未接受PCB的大鼠中，酶系统的活性随着蛋白质水平的升高而增加，直至约35%。在短期实验（8 - 9天）中，日粮中的PCB会导致酶系统活性增加，而与日粮蛋白质水平无关。然而，在半长期实验（29 - 30天）中，35 - 55%蛋白质日粮的诱导程度不同。因此，在此期间，10 - 20%蛋白质日粮的酶活性最高。高蛋白日粮通常会增强尿抗坏血酸和血清胆固醇的增加。在半长期实验中，尿抗坏血酸和血清胆固醇的最大增加分别出现在蛋白质含量为20%和35%时。与血清胆固醇相反，低蛋白日粮会显著增强PCB导致的肝脏胆固醇和甘油三酯的积累。
